Using a personality typing approach, we investigated the relationship between personality profiles and the prediction of longterm illness severity in patients with bipolar disorder BD. While previous research suggests associations between BD and traits from the NEO-FFI profiles, the current study firstly aimed to identify latent classes of NEO-FFI profiles, and, secondly, to examine their impact on the longterm prognosis of BD. Based on the NEO-FFI profiles of euthymic patients diagnosed with BD Subgroups of patients with BD share a number of discrete personality features and their illness is characterized by a similar clinical course. This knowledge is valuable in a variety of clinical contexts including early detection, intervention planning and treatment process. Refubium - Repositorium der Freien Universität Berlin. In ihrem Browser ist JavaScript deaktiviert. Einige Funktionen dieser Seite funktionieren ohne JavaScript nicht. Mikronavigation Startseite Weitere wissenschaftliche Publikationen Dokumente FU Dokumentanzeige. The big five model in bipolar disorder: a latent profile analysis and its impact on longterm illness severity Haupttitel:. The big five model in bipolar disorder: a latent profile analysis and its impact on longterm illness severity. Datum der Freigabe:. Background Using a personality typing approach, we investigated the relationship between personality profiles and the prediction bipolar disorder and dating longterm illness severity in patients with bipolar disorder BD. Methods Based on the NEO-FFI profiles of euthymic patients diagnosed with BD Conclusions Subgroups of patients with BD share a number of discrete personality features and their illness is characterized by a similar clinical course. Teil des Identifiers:. Freie Schlagwörter:. Bipolar disorder Big five Personality bipolar disorder and dating Morbidity index Illness course Medical and Health Sciences. URL der Originalausgabe:. DOI der Originalausgabe:. Erziehungswissenschaft und Psychologie Arbeitsbereich Entwicklungswissenschaft und Angewandte Entwicklungspsychologie. Zur Langanzeige. Prüfsumme MD5 : ffec6b1ff88e75d80b73c7e. Öffnen Dropdown öffnen Speichern. Creative Commons: Namensnennung. Excel CSV BibTeX.
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PDF | Deficits of theory of mind and empathy have been reported in bipolar disorder and schizophrenia Daten, MASC-Para-. Here we show that the disease-associated ADCY2 missense mutation diminishes the enzyme´s capacity to generate the second messenger 3',5'-cylic. meter und IRI-Ska-. We investigated the relationship between personality profiles and the prediction of longterm illness severity in patients with bipolar disorder (BD). Whether you have bipolar disorder or are dating someone with the condition, learn what you can do to maintain a healthy and fulfilling.J Neurosci. Differential cAMP signaling at hippocampal output synapses. LSE performed cell culture experiments. Munich Cluster of Systems Neurology SyNergy , Munich, Germany. Masana MI, Bitran JA, Hsiao JK, Mefford IN, Potter WZ. Finally, scRNA-Seq revealed that Adcy2 is not only widely expressed in the murine brain but is also present in a variety of different cell types, albeit the ValLeu missense mutation did not have an impact on the expression of Adcy2 mRNA itself in any of the identified cell clusters thereby confirming the bulk expression analysis in the cortex based on RT-qPCR Fig. The altered frequency of mEPSCs and mIPSCs suggest alterations in synaptic release probabilities. Taken together, these findings suggest a redistribution of the ADCY2-L variant from the plasma membrane to intracellular compartments. Article PubMed PubMed Central CAS Google Scholar Perry W, Minassian A, Henry B, Kincaid M, Young JW, Geyer MA. Therefore, we assessed whether the mania-like state presented by homozygous mutant Adcy2 VL mice could be reversed by lithium treatment. We thank Marcella Rietschel and Andreas Forstner for scientific discussion and advice. Ikeda M, Takahashi A, Kamatani Y, Okahisa Y, Kunugi H, Mori N, et al. An ECNP expert meeting report. Cichon S, Muhleisen TW, Degenhardt FA, Mattheisen M, Miro X, Strohmaier J, et al. Article PubMed PubMed Central CAS Google Scholar Razzoli M, Andreoli M, Maraia G, Di Francesco C, Arban R. PLoS One. DE EN RU. At first place, we confirmed previously observed signs of mania-like behavior in the untreated control group of L mice, i. Animals were allocated to the experimental groups in a semi-randomized manner and data analysis was performed blinded to the group allocation. Shahoha M, Cohen R, Ben-Simon Y, Ashery U. Genome-wide association study of 40, individuals identifies two novel loci associated with bipolar disorder. Zusammenfassung This paper addresses an important yet neglected existential issue sometimes faced by persons with bipolar disorder BD : confusion about the extent to which what one is like is influenced by BD. Published : 13 July General Conditions of Contract. Exposure to chronic social defeat stress switches homozygous Leu variant carriers from a mania- to a depressive-like state, a transition which is reminiscent of the alternations characterizing the symptomatology in BD patients. Particularly, the exposure to stressful life events is one factor that has been linked to the development of BD [ 41 , 42 , 43 ]. To resolve the cellular expression of Adcy2 mRNA and to assess whether the ValLeu missense mutation has any impact on downstream gene expression, we performed scRNA-seq on the ventral hippocampus vHPC of WT and L mice as previously described [ 36 , 37 ]. Statistical analyses were performed using the commercially available software GraphPad Prism v5. Logan RW, McClung CA. Adcy2 VL mice were tested in a battery of behavioral paradigms to assess locomotion, exploratory and anxiety-related behavior, stress-coping strategies and cognitive performance. Following 3 weeks of CSDS, Adcy2 VL mice showed increased adrenal gland Fig. If desired, relatives can be closely involved in the treatment, for example in discussions with the doctor. Time-dependent measures were assessed with multi-factorial analysis of variance ANOVA with repeated measures.
